2012;166:938-47. Sahebnasagh A, Ghasemi A, Akbari J, et al. J Burn Care Rehabil 1988;9:156-9. Make sure to follow the specific product instructions and take as directed on the label, or consult a licensed healthcare practitioner before use. Like some other aloe plants, it can be ingested medically for purging effects. View abstract. Antiinflammatory C-glucosyl chromone from Aloe barbadensis. View abstract. 2018 Jan 14. doi: 10.2174/1570163815666180115093007. 2007;(4):CD000978. View abstract. View abstract. McDaniel HR and McAnalley BH. Asian Biomedicine 2009;3(4):375-382. A type of inflammatory bowel disease (ulcerative colitis). Common side effects of aloe include: blood sugar (hypoglycemia) Burning and itching of the skin (infrequent) Stomach pain and cramps (high doses) View abstract. Eur J Cancer 1998;34:1091-8. Effects of aloe sterol supplementation on skin elasticity, hydration, and collagen score: a 12-week double-blind, randomized, controlled trial. Alkhouli M, Laflouf M, Alhaddad M. Efficacy of Aloe-vera use for prevention of chemotherapy-induced oral mucositis in children with acute lymphoblastic leukemia: A randomized controlled clinical trial. Interventions for treating oral lichen planus: a systematic review. J Altern Complement Med. Quintessence Int 2012;43(9):793-800. Aliment Pharmacol Ther 2004;19:521-7. Suksombon N, Poolsup N, Punthanitisarn S. Effect of aloe vera on glycaemic control in prediabetes and type 2 diabetes: a systematic review and meta-analysis. Cape aloe may cause diarrhea and strong cramping. Efficacy of aloe vera gel in the treatment of vulval lichen planus. Cochrane Database Syst Rev. Acute bullous allergic dermatitis due to local application of aloe leaves. But not all research agrees. Lee, H. Z., Lin, C. J., Yang, W. H., Leung, W. C., and Chang, S. P. Aloe-emodin induced DNA damage through generation of reactive oxygen species in human lung carcinoma cells. View abstract. View abstract. Gallagher J, Gray M. Is aloe vera effective for healing chronic wounds? Cochrane.Database.Syst.Rev. Some laxatives can decrease potassium in the body. Native to Southern Africa, it is colloquially called ‘bitter aloe’ or ‘cape aloe’. 2010 Nov 9;4:e879. View abstract. These are some of the side effects of aloe vera you must know about: Aloe latex, which is a component of the aloe vera leaf may be unfit for consumption. View abstract. 1996;3(3):245-248. Evaluation of a prescription strength 4% hydroquinone/10% L-ascorbic acid treatment system for normal to oily skin. Rieger, L. and Carson, R. E. The clinical effects of saline and aloe vera rinses on periodontal surgical sites. Planta Med 1993;59:A689. Lin, S. Y., Yang, J. H., Hsia, T. C., Lee, J. H., Chiu, T. H., Wei, Y. H., and Chung, J. G. Effect of inhibition of aloe-emodin on N-acetyltransferase activity and gene expression in human malignant melanoma cells (A375.S2). Aloe africana, Aloe arborescens, Aloe barbadensis, Aloe Capensis, Aloe ferox, Aloe frutescens, Aloe Gel, Aloe indica, Aloe Latex, Aloe Leaf Gel, Aloe natalenis, Aloe Perfoliata, Aloe perryi, Aloe spicata, Aloe supralaevis, Aloe ucriae, Aloe Vera Barbenoids, Aloe Vera Gel, Aloe vera, Aloes, AloÃ¨s, AloÃ¨s de CuraÃ§ao, AloÃ¨s des Barbades, AloÃ¨s du Cap, AloÃ¨s Vrai, AloÃ¨s Vulgaire, Arborescens natalenis, Barbados Aloe, Burn Plant, Cape Aloe, Chritkumari, Curacao Aloe, Elephant's Gall, Gel de la Feuille d'AloÃ¨s, Ghee-Kunwar, Ghi-Kuvar, Ghrita-Kumari, Gvar Patha, Hsiang-Dan, Indian Aloe, Jafarabad Aloe, Kanya, Kidachi Aloe, Kumari, Latex d'AloÃ¨s, Lily of the Desert, Lu-Hui, Miracle Plant, Plant of Immortality, Plante de l'ImmortalitÃ©, Plante de la Peau, Plante de Premiers Secours, Plante Miracle, Plantes des BrÃ»lures, SÃ¡bila. CMAJ. Planta Med 1989;55(6):509-512. Phytomedicine. View abstract. View abstract. Bottenberg MM, Wall GC, Harvey RL, Habib S. Oral aloe vera-induced hepatitis. Burning pain in the mouth. Evaluation of the anti-angiogenic effect of aloe-emodin. Clear Evidence of Carcinogenic Activity by a Whole-Leaf Extract of Aloe barbadensis Miller (Aloe vera) in F344/N Rats. Sevoflurane is used as anesthesia during surgery. Heliyon. J Altern.Complement Med. View abstract. Teplicki E, Ma Q, Castillo DE, et al. Ai.Zheng. Cutan Ocul Toxicol. View abstract. View abstract. Hepatogastroenterology 1990;37(6):601-605. Int J Radiat Oncol Biol Phys. Coopoosamy RM, Naidoo KK. 2008;17:1963-72. 1999;47(3):268-272. J.Drugs Dermatol. Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. A. 2020;32(8):e13860. Rev Cuba Med Gen Integr 1993;9:43-51. Shoji, A. View abstract. Most research shows that taking aloe by mouth can reduce, An inflammatory condition that causes rash or sores on the skin or mouth (, Obesity. It is also a source for the clear and … View abstract. Vardy AD, Cohen AD, and Tchetov T. A double-blind, placebo-controlled trial of Aloe vera (A. barbadensis) emulsion in the treatment of seborrheic dermatitis. Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others. Williams MS, Burk M, Loprinzi CL, et al. 1996;3(3):241-243. Aloe gel applied to the skin may cause burning and itching. View abstract. View abstract. Aloe vera helps ulcerative colitis. View abstract. View abstract. Alvarez-Perea, A., Garcia, A. P., Hernandez, A. L., de, Barrio M., and Baeza, M. L. Urticaria due to aloe vera: a new sensitizer? They are most definitely “bitter” which means they are good for the body. Rajar UD, Majeed R, Parveen N, et al. Yagi, A., Kabash, A., Okamura, N., Haraguchi, H., Moustafa, S. M., and Khalifa, T. I. Antioxidant, free radical scavenging and anti-inflammatory effects of aloesin derivatives in Aloe vera. chinensis. View abstract. Shah, S. A., DiTullio, P., Azadi, M., Shapiro, R. J., Eid, T. J., and Snyder, J. Gao, M., Singh, A., Macri, K., Reynolds, C., Singhal, V., Biswal, S., and Spannhake, E. W. Antioxidant components of naturally-occurring oils exhibit marked anti-inflammatory activity in epithelial cells of the human upper respiratory system. Skin damage caused by radiation therapy (radiation dermatitis). A mild form of gum disease (gingivitis). View abstract. Contact dermatitis to Aloe arborescens. More research is needed. Arch Dermatol. Aloe vera dermal wound gel is associated with a delay in wound healing. Kaufman T, Kalderon N, Ullmann Y, Berger J. Aloe vera gel hindered wound healing of experimental second-degree burns: a quantitative controlled study. View abstract. Koch A. 2017 Nov;23(11):858-65. View abstract. 2011;(4):CD000978. Phytother Res 1993;7:S37-S42. [Letter.]. Oral Surg Oral Med Oral Pathol Oral Radiol 2013;116(6):717-24. J Dermatolog Treat 2014;25(2):123-9. Pradeep AR, Agarwal E, Naik SB. Puataweepong P, Dhanachai M Dangprasert S Sithatani C Sawangsilp T Narkwong L et al. View abstract. The effect of aloe gel/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy. Cochrane Database Syst Rev. Barbadensis Leaf Water, Aloe Ferox Leaf Extract, Aloe Ferox Leaf Juice, and Aloe Ferox Leaf Juice Extract. Singh, R. P., Dhanalakshmi, S., and Rao, A. R. Chemomodulatory action of Aloe vera on the profiles of enzymes associated with carcinogen metabolism and antioxidant status regulation in mice. A placebo-controlled, double-blind, comparative study. Early research suggests that applying a cream containing aloe gel and olive oil three times daily for 10 days reduces the severity of diaper rash in children younger than 3-years-old. View abstract. Diabetes medications are also used to lower blood sugar. Choi HC, Kim SJ, Son KY, Oh BJ, Cho BL. 2008;21:106-10. Aloe gel might decrease blood sugar. Esua, M. F. and Rauwald, J. W. Novel bioactive maloyl glucans from aloe vera gel: isolation, structure elucidation and in vitro bioassays. Those words truly describe the Cape Aloe Bitter Crystals from The House of Aloes in South Africa. Journal of the European Academy of Dermatology & Venerology 1996;7(3):294-295. 2012;78:311-6. Aloe vera dermal wound gel is associated with a delay in wound healing. Studies of aloe. Sevoflurane also decreases clotting of the blood. 1989;80:513-20. J Nat Prod 1996;59:541-3. Some early research suggests that using a toothpaste containing aloe daily for 24 weeks reduces plaque. Other symptoms of IBS include cramping, abdominal pain, flatulence, and bloating. J Oral Pathol Med. View abstract. 1998;11:273-6. Angiology 1985;36(8):485-492. Some research shows that taking aloe might help with symptoms of IBS. View abstract. Research suggests that applying an aloe gel in the morning and evening, in addition to a prescription anti-acne medicine, improves acne by about 35% in both children and adults. J Dermatol.Surg.Oncol 1990;16(5):460-467. Khorasani G1, Ahmadi A, Jalal Hosseinimehr S, Ahmadi A2, Taheri A, et al. "Water pills" can also decrease potassium in the body. J Pharm Pharmacol 2000;52(5):593-598. View abstract. I. View abstract. Inflammation and damage to the rectum due to radiation therapy. View abstract. Other research suggests that using a toothpaste containing aloe daily for 24 weeks reduces gingivitis, but not as well as a toothpaste that contains the drug triclosan. Other side effects include abdominal cramps and diarrhea. Stretch marks. View abstract. Possible interaction between sevoflurane and Aloe vera. View abstract. Biol Pharm Bull. View abstract. Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasms. View abstract. Early research suggests that applying aloe twice daily for 4-6 weeks improves dandruff. Rev.Bras.Enferm. Eur Arch Paediatr Dent. Alvagel as a therapeutic agent in the treatment of roentgen and radium burns. The effect of aloe vera and tea tree oil mouthwashes on the oral health of school children. Heck E and Head M. Aloe vera gel cream as a topical treatment for outpatient burns. Aloe vera leaf gel: a review update. Double-blind placebo-controlled pilot trial of acemannan in advanced human immunodeficiency virus disease. Leng H, Pu L, Xu L, Shi X, Ji J, Chen K. Effects of aloe polysaccharide, a polysaccharide extracted from Aloe vera, on TNF-a-induced HaCaT cell proliferation and the underlying mechanism in psoriasis. World J Gastroenterol 2005;11:303-4. Some drugs and herbal products: IARC monographs on the evaluation of carcinogenic risks to humans, Volume 108. 2-15-1988;138(4):336-338. Dal'Belo SE, Gaspar LR, Maia Campos PM. LÃ³pez-Jornet P, Camacho-Alonso F, Molino-Pagan D. Prospective, randomized, double-blind, clinical evaluation of Aloe vera Barbadensis, applied in combination with a tongue protector to treat burning mouth syndrome. A., Ahmad, S. A., and Ahmad, S. H. Human leukocyte interferon-alpha in a hydrophilic cream versus in a gel for the treatment of genital herpes in males: a placebo-controlled, double-blind, comparative study. 2009;23:171-5. Clinical trial in diabetes mellitus patients in combination with glibenclamide. … How Aloe Ferox is effective for various diseases is listed in repertory format. Thongprasom K, Carrozzo M, Furness S, et al. J Matern Fetal Neonatal Med. Cascara sagrada, aloe laxatives, O-9 contraceptives are category II-FDA. 2012;83:797-804. Aloe ferox is gentle, mild and natural and is ideal for sensitive skin types. 2008;16:293-6. Rhein and aloe-emodin kinetics from senna laxatives in man. Wounds 1995;7(5):200-202. Anuradha A, Patil B, Asha VR. Avoid aloe juice during pregnancy or breast-feeding. Curr.Diab.Rep. Radiol Rev Chicago Med Recorder 1935;57(6):137-138. Curr.Ther Res.Clin.Exp 1974;16(8):817-820. Luyckx VA, Ballantine R, Claeys M, Cuyckens F, Van den Heuvel H, Cimanga RK, Vlietinck AJ, De Broe ME, Katz IJ. J Altern Complement Med. Early research suggests that taking 400 mg of a chemical that comes from aloe four times daily does not improve immune function in people with human immunodeficiency virus (HIV). Early research in people with oral submucous fibrosis shows that applying aloe gel reduces burning. J.Oral Pathol.Med. Long-term use of large amounts of aloe latex … 1998;86:550-6. Am J Med Sci. 2012;31:95-103. for treatment of minor burns. 2012;2:CD008092. Puentes Sanchez J., Pardo Gonzalez, C. M., Pardo Gonzalez, M. B., Navarro Casado, F. J., Puentes, Sanchez R., Mendez Gonzalez, J. M., Gonzalez, Rojo J., Juarez, Morales A., and Lopez, Fernandez, I. Some research also shows that applying aloe cream reduces wound size compared to applying, Diabetes. BMC Complement Altern Med 2018;18(1):264. doi: 10.1186/s12906-018-2326-2. J Oral Pathol Med 2017 Jan;46(1):50-55. Management of psoriasis with Aloe vera extract in a hydrophilic cream: a placebo-controlled, double-blind study. Randomized trial of aloe vera gel vs triamcinolone acetonide ointment in the treatment of oral lichen planus. View abstract. When taken by mouth aloe latex is a type of laxative called a stimulant laxative. Toxicol Sci. 2020;21(1):61-66. Clinical trial in diabetes mellitus patients in combination with glibenclamide. Lee, T. and Dugoua, J. J. Nutritional supplements and their effect on glucose control. Melanoma Res 2005;15(6):489-494. PLoS Negl Trop Dis. View abstract. Preliminary study of effectiveness of aloe vera in scabies treatment. Pecere, T., Sarinella, F., Salata, C., Gatto, B., Bet, A., Dalla, Vecchia F., Diaspro, A., Carli, M., Palumbo, M., and Palu, G. Involvement of p53 in specific anti-neuroectodermal tumor activity of aloe-emodin. Aloe vera extract 0.5% in hydrophilic cream versus aloe vera gel for the measurement of genital herpes in males. View abstract. Side Effects of Aloe … Garnick JJ, Singh B, Winkley G. Effectiveness of a medicament containing silicon dioxide, aloe, and allantoin on aphthous stomatitis. Use caution with cosmetic products containing A. vera gel. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Panahi Y, Davoudi SM, Sahebkar A, et al. Aloe vera extract 0.5% in hydrophilic cream versus aloe vera gel for the measurement of genital herpes in males. Olatunya OS, Olatunya AM, Anyabolu HC, et al. 1980;116(9):1064-1065. These effects combined suggest that Cape Aloe gel can speed up the process of wound healing. Where did you or where do you plan to purchase this product? If you take warfarin, do not to take excessive amounts of aloe latex. Plemons J, Rees TD Binnie WH, et al. Mechanism of cathartic effect. Siriraj Hospital Gazette 1991;43(5):31-36. J Urol 2006;175(1):343-347. Phillips T, Ongenae K Kanj L Slater-Freedberg J. Effect of anthraquinone laxatives on the proliferation and urokinase secretion of normal, premalignant and malignant colonic epithelial cells. Stimulant laxatives speed up the bowels. Most research shows that applying aloe gel or cream to the skin can reduce healing time in people with first- or second-degree burns. Ghannam, N., Kingston, M., Al Meshaal, I. Odontology. Simao, D. A., Lima, E. D., Souza, R. S., Faria, T. V., and Azevedo, G. F. [Hand-foot syndrome induced by chemotherapy: a case study]. Eur Rev Med Pharmacol Sci 2014;18(7):1078-84. Williams LD, Burdock GA, Shin E, Kim S, Jo TH, Jones KN, Matulka RA. Aloe Fernex has higher nutrient concentrations than the more common Aloe Vera. Yongchaiyudha S, Rungpitarangsi V, Bunyapraphatsara N, and et al. It might be safe when appropriate doses are taken orally for a short time.Aloe latex or whole-leaf extract taken orally might be unsafe and is likely unsafe in high doses. Journal of the European Academy of Dermatology & Venerology 1996;7:294-95. Skin Pharmacol Physiol. The effect of Aloe Vera gel on prevention of pressure ulcers in patients hospitalized in the orthopedic wards: a randomized triple-blind clinical trial. Puvabanditsin P, Vongtongsri R. Efficacy of aloe vera cream in prevention and treatment of sunburn and suntan. J Coll Physicians Surg Pak. Medications taken by mouth (Oral drugs) interacts with ALOE. The aloe cream was used along with a sitz bath three times daily, laxatives, and eating a full fiber diet. 1989 Oct;6:237-9. Schmidt JM and Greenspoon JS. BMJ Case Rep 2012;2012. Applying aloe twice daily, starting at week 16-18 of pregnancy, might improve the redness and itching of stretch marks in women pregnant with their first child. View abstract. Phytomedicine 1996;3(3):241-243. II. Di Franco R, Sammarco E, Calvanese MG, De Natale F, Falivene S, Di Lecce A, Giugliano FM, Murino P, Manzo R, Cappabianca S, Muto P, Ravo V. Preventing the acute skin side effects in patients treated with radiotherapy for breast cancer: the use of corneometry in order to evaluate the protective effect of moisturizing creams. Surgery: Because of its interference with your blood sugar levels, it is suggested to stop using aloe … A placebo-controlled, double-blind, comparative study. de Witte, P. and Lemli, L. The metabolism of anthranoid laxatives. View abstract. Wounds 2018;30(9):263-8. Detoxification effects of aloe polysaccharide and propolis on the urinary excretion of metabolites in smokers. View abstract. J Altern Complement Med. Worthington HV, Clarkson JE, Bryan G, et al. ScientificWorldJournal. Thick, raised scars (hypertrophic scars). J Clin Epidemiol 1997;50(suppl 1):3S. Itchy skin infection caused by mites (scabies). Am J Roentgenol 1935;33(3):396-397. 2012;29(2):e1103-e1112. Visuthikosol V, Chowchuen B, Sukwanarat Y, et al. Bunyapraphatsara, N., Yongchaiyudha, S., Rungpitarangsi, V., and Chokechaijaroenporn, O. Antidiabetic activity of Aloe vera L. juice II. Photodermatol. 2002 Mar;39(3):E13. 2005;19:326-31. Effects of oral Aloe vera on electrocardiographic and blood pressure measurements. View abstract. Pharmacology 1993;47(suppl 1):120-124. 2003;69(3):269-271. View abstract. Cape aloe is similar to aloe vera, except that cape aloe leaf has more laxative properties. Also, other research suggests that applying aloe gel does not seem to delay new canker sores. View abstract. 2005;28(6):482-485. View abstract. 2012;2012:810234. View abstract. Am J Infect Control. Br J Dermatol. Evaluation of the efficacy of two mouthrinses formulated for the relief of xerostomia of diverse origin in adult subjects. View abstract. Burns 2003;28:834-6.. View abstract. Some research shows that applying a gel containing aloe to the gums after getting dental appliances helps to prevent mouth sores. Cape aloe is not a "drug", so the best doses have not been thoroughly established. 1976;14 Suppl 1:73-7. Worthington, H. V., Clarkson, J. E., and Eden, O. Because cape aloe latex is so potent, the University of Maryland Medical Center cautions against using it as a single-ingredient medication for constipation. J Okla.Dent.Assoc 2002 ; 68 ( 11 ):957-960 & Venerology 1996 ; 36:345-9 may from... 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