Azobenzene (AZB) is non-carcinogenic in mice, but a potent rat carcinogen, inducing tumours in the spleen and other abdominal organs. It is therefore not possible to determine a level of intake for aniline which may be regarded as safe for humans. 5.2 Human carcinogenicity data At the present time, the weight of epidemiological evidence suggests that aniline is not a carcinogen for the human bladder. There is no legal or scientific reference or study related safe limit values for aniline. (A substance that causes cancer or helps cancer grow is called a carcinogen.) GROUP 1: the agent may be a carcinogenic mixture for humans (proven carcinogen or certainly carcinogenic). The American Cancer Society looks to these organizations to evaluate the risks based on evidence from laboratory, animal, and human research studies. Nitrobenzene has a synergistic effect on the toxicity of aniline and o-toluidine [5]. Is Aniline Carcinogen? It causes kidney, urethra, bladder, and hematological neoplasia. IARC Monographs on the Identification of Carcinogenic Hazards to Humans. Heart, kidney, and liver damage may also occur, possibly as secondary effects of hemolysis Considered a Non Threshold carcinogen : In the past, benzidine was used to produce dyes or products used in clinical laboratories. EPA has classified hydrazine as a Group B2, probable human carcinogen. Aniline is a colourless, oily liquid which turns brown on exposure to light and air. Based on animal studies the Panel concluded that aniline should be considered as a carcinogen [ 3 ]. IRIS (U.S. EPA, 2007) has classified aniline as a probable human carcinogen (Group B2), based on an increased incidence of sarcomas of the spleen and other organs in two strains of rats exposed orally to aniline hydrochloride (CIIT,1982; NCI, 1978) and supporting genetic toxicity evidence. The approximate minimum lethal dose for a 150 lb. A number of the carcinogen classifications deal with groups of substances: aniline and homologs, chromates, dintrotoluenes, arsenic and inorganic arsenic compounds, beryllium and beryllium compounds, cadmium compounds, nickel compounds, and crystalline forms of silica. Aniline can irritate the eyes with possible eye damage. www.efsa.europa.eu. Vapour affects the eyes and lungs and reduces the ability of blood to carry oxygen. Aniline has been evaluated as a carcinogen. Dietary Supplement Label Database (DSLD): The Dietary Supplement Label Database (DSLD) (https://dsld.od.nih.gov) includes full label derived information from dietary supplement products marketed in the U.S. with a Web-based user interface that provides ready access to label information. In addition to the concerns related to the genotoxicity and carcinogenicity, it can cause methemoglobinemia and haemolytic anaemia after long term exposure. The exposure circumstance entails exposures that are carcinogenic to humans. Current OSHA PEL: 5 ppm (19 mg/m3) TWA [skin] 1989 OSHA PEL: 2 ppm (8 mg/m3) TWA [skin] 1993-1994 ACGIH TLV: 2 ppm (7.6 mg/m3) TWA [skin] Description of substance: Colorless to brown, oily liquid with an aromatic amine-like odor. IARC. The International Agency for Research on Cancer (IARC) determined that aniline is not classifiable as to its carcinogenicity to humans. Loading… Aniline CAS RN: 62-53-3 Carcinogenicity Evidence. Subsequent evaluations: Vol. EPA calculated an inhalation unit risk estimate of 4.9 × 10 -3 (µg/m 3)-1. • USEPA: suggests that Aniline could be a suspected carcinogen and there is no evidence of being carcinogenic by itself. aniline in adult man is about 0.21 mg/kg body weight Chronic exposure Anemia, headaches, tremor, parathesia, pain, narcosis or coma, and cardiac arrhythmia. Inhaling Aniline can irritate the nose and throat. the industry in general does not consider aniline as a risk from a consumer safety perspective. Its EINECS register number is 200-539-3 and CAS register number is 62-53-3. Aniline is incompatible with oxidizing agents, bases, acids, iron and iron salts, zinc, aluminium. Current OSHA PEL: 5 ppm (19 mg/m3) TWA [skin] 1989 OSHA PEL: 2 ppm (8 mg/m3) TWA [skin] 1993-1994 ACGIH TLV: 2 ppm (7.6 mg/m3) TWA [skin] Description of substance: Colorless to brown, oily liquid with an … LEL: … Nitrobenzene is toxic and poisonous. Acetanilide can be produced by reacting acetic anhydride with aniline: C 6 H 5 NH 2 + (CH 3 CO) 2 O → C 6 H 5 NHCOCH 3 + CH 3 COOH. human is 10 grams. Learn about benzidine, exposure to which raises your risk of bladder cancer. Aniline is classified as a suspected carcinogen (carcinogen category 2) under the Classification, Labelling and Packaging Regulation (CLP) in the EU. The present paper shows that AZB clearly induces micronuclei in the bone marrow of rats at a dose of 375 mg/kg and above. List of Classifications. ... Metolachlor can increase the incidence of liver tumors in rats and has been classified as a possible human carcinogen (Monsanto, 1991; Wilson and Takei, 1999; Heydens et al., 2010). This site is now being updated and maintained for access by the NIH Office of Dietary Supplements It is rapidly absorbed by all routes and induces methemoglobinemia. VOL. Uses advised against Food, drug, pesticide or biocidal product use Details of the supplier of the safety data sheet Emergency Telephone Number CHEMTRECÒ, Inside the USA: 800-424-9300 CHEMTRECÒ, … What are aniline dyes and how did such a plant end up in Nyack? Aniline can cause skin irritation and rash. The human carcinogen potency factor (q1*) for aniline is .026 (mg/kg/day)-1 for oral exposure. Based on animal and human evidence, several expert agencies have evaluated the cancer-causing potential of benzene. The same carcinogen can give rise to tumors of different kinds and locations, depending on the site of application, and a given type of tumor can be caused by different substances. The available studies in humans are inadequate to determine whether exposure to aniline can increase the risk of developing cancer in people. Aniline is a chemical byproduct of treated coal tar, which was an abundant waste product of the time. Serious poisoning may result from ingestion of 0.25 mL. threshold carcinogen, as confirmed by the Committee for Risk Assessment of the European Chemicals Agency (RAC) who indicated, in its opinion on restriction of substances in tattoo inks and permanent make-up8, that aniline is considered a non-threshold carcinogen. Benzidine is a manufactured chemical. BUT, rats that ate food contaminated with aniline for life developed cancer of the spleen. Exposure levels at the garment stage, especially those having undergone garment-washing processes, were low. carcinogen. CAS number: 62-53-3 NIOSH REL: None established; NIOSH considers aniline to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990]. However, benzidine has not been sold in the United States since the mid-1970s. In mice, however, only a marginally positive … : 4 (1974) (p. 27) 5. 000062-53-3 Aniline 3 27, Sup 7 1987 000090-04-0 ortho-Anisidine 2B Sup 7, 73 1999 000104-94-9 para-Anisidine 3 27, Sup 7 1987 000191-26-4 Anthanthrene 3 92, Sup 7 2010 000120-12-7 Anthracene 3 92, Sup 7 2010 000118-92-3 Anthranilic acid 3 16, Sup 7 1987 000084-65-1 Anthraquinone 2B 101 2013 001309-64-4 Antimony trioxide 2B 47 1989 001345-04-6 Antimony trisulfide 3 47 1989 000052-46-0 … Until recently, these inadequate experiments plus the publication of a series of epidemiologic studies that exonerated aniline as a bladder carcinogen have led to the belief that aniline is not a carcinogen. It is considered to have high acute toxicity, based on short-term animal tests in rats. Symptoms of methemoglobinemia include cyanosis, headache, dizziness, weakness, lethargy, loss of coordination, dyspnea, coma, and death. : A740I-4; A740I-500 CAS-No 62-53-3 Synonyms Phenylamine; Aminobenzene; Benzenamine (Certified ACS) Recommended Use Laboratory chemicals. The International Agency for Research on Cancer (IAR It is soluble in water, ether, ethanol and most organic solvents. The carcinogen aniline is negative in the Ames Salmonella mutagenicity assay. Aniline should be handled as a CARCINOGEN--WITH EXTREME CAUTION. The formation of methemoglobin interferes with the oxygen-carrying capacity of the blood. N-Nitroso-N-methylaniline (NMA) is an esophageal carcinogen in the rat. Although aniline is "only" a category 2 carcinogen (remember formaldehyde?) In 1978, the results of a carcinogenesis bioassay in rats and mice given aniline hydrochloride were released. Some authorities class aniline as a carcinogen, although the IARC lists it in Group 3 (not classifiable as to its carcinogenicity to humans) due to the limited and contradictory data available. It is toxic and a suspected carcinogen which is readily absorbed by the skin. GOTS position on Aniline Aniline is known to possess slight contact sensitising potential. Product Name Aniline Cat No. A Heinz-body hemolytic crisis may follow the development of methemoglobinemia by 2 to 7 days. The process for converting aniline, which has the odor of rotten fish, to a colored dye when treated by acids was discovered by accident in England in 1856. NIOSH REL: None established; NIOSH considers aniline to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990]. Classification of carcinogenicity: Overall summary evaluation of carcinogenic risk to humans is Group 3: The agent is not classifiable as to its carcinogenicity to humans. Beginning of August 2012, 108 agents are classified in Group 1 of IARC. Chronic Effects . Aniline has been classified as very toxic in humans, with a probable oral lethal dose in humans at 50 to 500 milligrams per kilogram body weight (mg/kg). Aniline poisoning is characterized by methemoglobin formation in the blood and resulting cyanosis or blue skin. (4) EPA uses mathematical models, based on human and animal studies, to estimate the probability of a person developing cancer from breathing air containing a specified concentration of a chemical. ANILINE. 1) Aniline is a skin and eye irritant and a mild dermal sensitizer. Aniline is an organic compound with the formula C 6 H 5 NH 2 which has the IUPAC name Phenylamine. Aniline does, however, induce intrachromosomal recombination between repeated sequences in Saccharomyces cerevisiae, resulting in deletion (DEL) of intervening sequences. Ethanol is flammable and a dangerous fire risk. Aniline may therefore cause cancer at even the slightest level of exposure. But interestingly, we have seen that aniline has started to appear on restricted substance lists, which … o-Toluidine is toxic and a potential human carcinogen. Aniline can cause methemoglobin formation, and liver and endocrine effects. The in vitro enzymatic metabolism of N-nitroso-N-methylaniline was investigated using cytochromes P450 2B1 and P450 2B2, isolated from liver microsomes of rats pretreated with phenobarbital (PB), reconstituted with NADPH-cytochrome P450 reductase and dilauroylphosphatidylcholine. This category is only used when sufficient indications of carcinogenicity for humans are available. Summary of Data Reported and Evaluation 5.1 Animal carcinogenicity data There is no adequate data to indicate that aniline is carcinogenic in experimental animals. Carcinogen List The following is a list of substances NIOSH considers to be potential occupational carcinogens. Given new scientific evidence, it cannot be excluded that aniline ’s carcinogenic potential is due to damage to the genetic material of the cells. CLASSIFICATION: B2; probable human carcinogen. The Reportable Quantity (RQ) value of 1, 10, 100, 1000, or 5000 pounds is used to determine the quantity of a hazardous substance for which notification is required in the event of a release as specified by CERCLA based on chronic toxicity. References ^ Thomas Kahl, Kai-Wilfrid Schröder, "Aniline" in Ullmann's Encyclopedia of Industrial Chemistry 2007; John Wiley & Sons: New York. SPECIAL PRECAUTIONS: Aniline is toxic, poisonous and a potential human carcinogen. Laboratory, animal, and death sensitising potential is `` only '' a category carcinogen! Is `` only '' a category 2 carcinogen ( remember formaldehyde? only a marginally positive … is aniline?! 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